You aren't a medical doctor a biologist or a mental health professional so I don't think you have any authority on the subject, which is essentially settled in all those fields. You are however a fat insane retard who almost gives Josh a run for his money, from my understanding.
I was a medical doctor and I have a BA in biology and a masters in immunology. AMA
To answer the obvious question. There is no primary genetic basis for gender. There is no "gender gene"; the same way there is no "gay gene" that has been identified.
What people refer to as "gender" are just secondary sexual characteristics and social behaviors largely motivated by the effects of sex hormones. Men who have to take spironolactone for genuine medical purposes, for example for high blood pressure, or for ascites often experience emotional and physical side effects such as erectile dysfunction, depression, gynecomastia, etc; because while spironolactone is prescribed as a diuretic, it's also used in conjunction with HRT estrogen as an anti-androgen/testosterone suppressant.
Men put on Spiro for genuine purposes can experience a shift, often noticeable, in their "gender expression" because it acts on the androgen receptors to block the uptake of testosterone and DHT.
If a person's behavior can be chemically altered despite living their lives as a man, knowing they're a man, etc then "gender" is a bullshit idea. It doesn't exist as an intrinsic property of the Self.
Also, liver complications or advanced cirrhosis can impair the function of the liver sufficiently that environmental estrogens which would be filtered out by a healthy hepatic system, stay in the blood stream and also affect a person psychologically and physiologically. It's common for men with liver failure to develop gynecomastia and experience behavioral changes.
Testosterone and Estrogen are the sole sources of all "gendered" behavior.
Any further questions?